Sentence examples for key functional domains from inspiring English sources

Three novel HCM-susceptibility mutations: S101R, Y141H and S165F, which localize to key functional domains, were discovered in 3/388 unrelated patients with HCM and were absent in 1000 ethnic-matched reference alleles.

*The key functional domains are defined in Figure  1.

GJW defined the coordinates of the MRN protein key functional domains and helped to draft the manuscript.

In this regard, animal studies have potential for identifying key functional domains that are affected by exposure and would be relevant to assess in human populations.

Missense substitutions were in key functional domains of Top2 and included changes in residues associated with resistance to chemotherapeutic drugs (Wu et al. 2011).

†Adjusted P value could not be calculated because some cells contained 0. *The key functional domains are defined in Figure  1.

Observations suggest that the propeptide is a key functional domain of ADAMTS9, mediating an unusual regulatory mechanism that may have evolved to ensure maximal activity of this protease at the cell surface.

Because this domain is required for double-strand break formation during meiosis but not for repair of double-strand breaks [ 46], the domain was not included in the list of 'key functional domains' and the indel was not included in statistical analyses of key functional domain variants.

$Eleven distinct key functional domain missense substitutions fall in this group (Table  4).

Key functional domain, common for human PARP9, PARP14 and PARP15 proteins is a macrodomain.

*Key functional domain rare missense substitutions with A-GVGD scores > C0, in-frame indels, and final exon nonsense and frameshift variants if they also fall in a key functional domain.