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Inducing the correct set of genes in a coordinated manner is a key for developmental pathway regulation and is often achieved through a transcriptional regulatory cascade [2], [3], [4].
Early identification and intervention is thus key for developmental disorders like autism.
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Therefore they might have cooperative role on IGF1R/PI3 K axis, a key pathway for developmental and malignant processes.
Knowledge on miRNAs in B. dorsalis could help in developing novel pest control strategies, for example, miRNAs that are specific for egg and larval stages, likely involved in key pathways for developmental transitions, can be further characterized and utilized in miRNA mimics feeding and plant expression [ 48, 49].
Transcriptional profiles of flower and developing fruit at three main stages have been integrated with their corresponding landmarks, which will be useful for identifying important regulatory components responsible for key developmental processes.
The precise control of gene expression is pivotal for key developmental processes during embryogenesis.
Fortunately, recent advances in RNA-seq technology have increased its potential in generating functional "omics data" and thus help in elucidating the molecular basis for key developmental processes.
Specific closure of plasmodesmata is important for key developmental events, because of the water movement and/or diffusion of other molecules.
For example, Denoeud et al. (Science 2011) found that the few genes with long introns in Oikopleura are enriched for key developmental regulators, and that those introns likely contain regulatory information.
The reeler mouse is a homozygous reelin-deficient mutant that, due to its striking cortical phenotype, provides "a valuable experiment in nature" (Caviness et al. 1988) for key developmental mechanisms like neuronal migration (Hashimoto-Torii et al. 2008; Britto et al. 2011) or pathway formation (Harsan et al. 2013).
Although symbolic numerical magnitude processing skills are key for learning arithmetic, their developmental trajectories remain unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com