Our proposed disease AOPs, like AOPs in toxicology, would describe a chain of causally linked key events causing downstream effects at several biological levels and provide clear mechanistic rationales for diagnostic, preventative, and therapeutic interventions in the era of personalized medicine.
The TEL/AML1 fusion may therefore not be the single key molecular event causing leukemia spread, and if this is the case, TEL/AML1-positive ALL might involve other critical gene modifications; any such modifications remain to be documented [ 6, 7].
In particular, most carcinogenic metals are weak mutagens and do not induce DNA adduct formation, a key initiating event caused by other carcinogens (Salnikow and Zhitkovich 2008).
The permeabilization of the membrane is due to the opening of the permeability transition pore, which is an early key event in apoptosis, causing activation of the caspase cascade through release of cytochrome c.
The event caused a national uproar.
Then suddenly an event causes an eruption.
Amyloid accumulation is considered a key event in AD pathology by causing glial activation, neuritic alteration, synaptic damage and neuronal death [ 34, 35, 42].
33 We used narrative as a sense making and synthesis tool to weave together the quantitative and qualitative findings into a rich picture of HealthSpace, which depicted key events and upstream causes while also conveying ambiguities and uncertainties.
Cardiovascular disease is a key event of interest and is a leading cause of death.
Thus, non-hospitalized COPD exacerbations are key events that not only cause symptomatic deterioration but also impair the patients' activity.
