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Patient reported outcome (PRO) measures, therefore, are commonly used as key endpoints for evaluating the efficacy of CRPC treatments.
Study findings support the importance of PRO measures of pain severity as key endpoints for evaluating the efficacy of treatments for CRPC, particularly for patients with bone metastases where episodes of BTcP are common.
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Maintaining and re-establishing connections of retinal ganglion cells to target neurons in major visual structures is a key endpoint for regenerative medicine strategies.
We defined a major adverse limb event (MALE) as a key endpoint for revascularization therapies in CLI inclusive of amputation (transtibial or above) or any major vascular reintervention (thrombectomy, thrombolysis, or major surgical procedure [new bypass graft, jump/interposition graft revision]) in the index limb.
The Cochrane systematic review of lactate measurement in labour identified the caesarean section rate as a key endpoint for the evaluation of this form of fetal welfare assessment [ 2].
In further support of Day 7 as the key endpoint for this meta-analysis untreated HK can take up to three weeks to resolve making resolution within a week a therapeutic success, and many of the original idoxuridine studies utilized a day seven endpoint in their analyses [ 6, 10].
A comparison of key endpoints will be made for mothers in all three groups.
The planned sample size of 300 patients in phase 2 was based on medical and feasibility considerations as well as power considerations for key endpoints.
For two key endpoints, ACR50 response and DAS28 change, supportive post hoc analyses used propensity scores [ 11] computed using a logistic regression model (Electronic supplementary material (ESM) Table S1).
Identity, provisioning and billing are the key endpoints that serve as the foundation for the service.
For the purposes of this paper, only the key endpoints used to derive chronic benzene toxicological benchmarks for risk assessment are summarized.
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