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Maintaining and re-establishing connections of retinal ganglion cells to target neurons in major visual structures is a key endpoint for regenerative medicine strategies.
We defined a major adverse limb event (MALE) as a key endpoint for revascularization therapies in CLI inclusive of amputation (transtibial or above) or any major vascular reintervention (thrombectomy, thrombolysis, or major surgical procedure [new bypass graft, jump/interposition graft revision]) in the index limb.
Importantly, the key endpoint of the model, AP-1 formation, is very reproducible across all treatment conditions.
For example, the incremental cost per QALY gained was a key endpoint in recent cost-effectiveness evaluations in CLL and chronic myeloid leukaemia (CML) [ 6- 8].
The Cochrane systematic review of lactate measurement in labour identified the caesarean section rate as a key endpoint for the evaluation of this form of fetal welfare assessment [ 2].
The high pre-vaccination seropositivity supports use of defined VRs as a key endpoint of the study, since it measures the percentage of participants that had a response to vaccination, rather than simply seropositivity.
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Survival, response, and quality of life (QoL) are considered the key endpoints of oncology clinical trials.
The durability of the immune response in vaccinees, as well as safety and efficacy in pregnant animals and prevention of mortality in neonatal animals will be key endpoints in such studies.
Unfortunately, this heterogeneity may lead to significant biases in the estimates of key endpoints, including nonrelapse mortality, relapse, GVHD, or engraftment.
EOGRTS design makes toxicity testing progressive, comprehensive, and efficient by assessing key endpoints across multiple life-stages at relevant doses using a minimum number of animals, combining studies/evaluations and proposing tiered-testing approaches based on outcomes.
Identity, provisioning and billing are the key endpoints that serve as the foundation for the service.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com