When fully bound, GltPh-R397A crystallizes in the outward-facing state, like wild type GltPh, except that L-asp coordination is slightly altered because the mutant is missing the key coordinating side chain of Arg397.
Early supplier involvement is a key coordinating process in supply chain design, product design and process design.
In particular, we analyze the relationship between the global and the local through an examination of two key coordinating mechanisms used by audit firms––inter-office instructions and the firm's risk based audit methodology.
"The UN is meant to have a key coordinating function, but usually, and in this, it's at best imperfect".
In view of this, it may be incumbent on the donor community to insert staff into key coordinating positions for a minimum of three years to ensure that systems and procedures are established and maintained through the development of institutional knowledge.
To guide the selection of these representatives, UNICEF set up a Task Force of NGO representatives that were selected on the basis of the key coordinating roles that they, and the organizations they represented, played at the time of the Special Session on Children in May 2002.
But, while the key internal coordinates were the JFK shooting and Watergate – scenes often take place in underground car parks, the favoured meeting place of the Watergate mole Deep Throat – the show owed much of its impact to the external atmosphere of post-cold war America, as dictatorships fell around the world and elected politicians struggled to find the right words for a free world.
Overall, we propose interstrand separation and salt-bridge formation as key reaction coordinates describing the structural transition of the small Aβ40 oligomers to fibrils.
A combination of both models is likely at play – but resolving the issue of where these key transcriptional coordinates are located is essential.
Virtually all experts agree that primary care physicians and their assistants are the key to coordinating patient care in our disjointed health care system.
