Overall, the most parsimonious model for this precedent of kinase isoform selectivity via targeting of the active site is one that maximizes of key chemical complementarities between MW150 and p38αMAPK.
BACKGROUND: Many computational microRNA target prediction tools are focused on several key features, including complementarity to 5'seed of miRNAs and evolutionary conservation.
QMC employs the monomolecular tetrahelical architecture of DNA and has two key components: (i) shape complementarity between QMC partners, which is introduced by specific modifications of the quadruplexes, and (ii) Mg2+ ions.
During the next decade, Bohr worked with physics to lay the foundation of the principles of quantum mechanics, and it was in 1927 that he developed the concept of complementarity, a key principle in quantum mechanics.
Frequently cited key concepts also include complementarity, which concerns selection of complementary areas to avoid duplication of effort, and threat and vulnerability, which concern the persistence of biodiversity features in focal areas (Margules & Pressey, 2000; Cabeza & Moilanen, 2001; Sarkar et al., 2006; Moilanen, 2008).
The key mechanism is an underlying complementarity between the entrepreneur and the inputs they employ.
Antibody and antigen interact by spatial complementarity (lock and key).
The identification of the key residues of scFv in the complementarity determining regions (CDRs) from the combination of the computational alanine scanning and pairwise decomposition energy calculation can be used to design the new potential scFv anti-p17.
It is for similar reasons that qualities like beauty and simplicity, synthesis and complementarity seem to hold the key to the discovery of truths, and hence are important guides when probing the mysteries of nature.
Much of that is down to the complementarity of their respective strengths – Key's thin-man falsetto the perfect alloy for Peele's squat basso profundo – and the sheer range of their performing ability across countless different subjects and in countless different keys.
Complementarity seems to be the key word, here.
