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Dickey credited Hough, a former knuckleballer, with making a key alteration to his throwing grip after the two met for the first time in 2005.
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Hyperglycaemia induces oxidative stress which increases profibrogenic factors leading to interstitial fibrosis, a key alteration in diabetic cardiomyopathy.
One further layer of complexity is the identification of key biological alterations to be selectively targeted by tailored therapies.
As a result, intensive research is currently underway to identify the key alterations that may prove to be important for both classification and prognosis prediction.
Gaga's rendition of The Star-Spangled Banner had one key alteration: as the a cappella number reached its apex, she changed a lyric to refer to the rainbow flag: "Oh, say does that star-spangled flag of pride yet wave/ O'er the land of the free and the home of the brave".
20 Common to most of these entities are: loss of SMARCB1 as a key alteration, rhabdoid cell component that varies from subtle (represented by a few scattered cells) to extensive comprising almost 100% of the neoplasm, and a frequently (but not obligatory) aggressive clinical course with widespread metastasis at time of diagnosis.
This is a key alteration in homeostasis since the stroma is normally restricted from access to proteins secreted by epithelium into the lumen within glandular tissues.
Increased glucose uptake is a key alteration associated with the high glycolytic rate of cancer cells (the Warburg effect) [ 5], and reprogramming of energy metabolism can now be viewed as one of the "hallmarks of cancer" [ 6].
It should be noted that such a model does not suggest the presence of regulatory 'master-switches' but rather the re-balancing of a complex system in response to key alterations.
Thus, using the rhesus monkey as a model, the present study was designed to examine several of these key alterations in the basal ganglia in order to help elucidate the mechanisms contributing to age-related motor decline.
Key alterations in adhesion molecules are known to dictate progression from the invasive to malignant phenotype followed by colonization at a distant site.
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