Sentence examples for key DNA from inspiring English sources

We hypothesize that the chromatin remodeling and homologous recombination defects observed in our patients' cancers prevented repair of 5-FU-induced DNA damage by interfering with two key DNA repair pathways (homologous recombination and PRR), leading to marked replication arrest.

BRCA1 as well as BRCA2 mutated tumours harbour defects in homologous repair, one of the key DNA repair pathways in response to double-strand DNA breaks [ 36].

Amongst these polymerases is PARP-1 which is the key DNA damage-sensing enzyme that acts as an initiator for the DNA repair mechanism.

Our results demonstrate a potential biological role for PARP1c and PARP1nc in DNA repair in BC based on the significant association with other key DNA damage repair proteins.

We focussed on key DNA repair and damage signalling factors, as the antitumour activity of platinum-based chemotherapy is largely dependent on the DNA repair capacity of cancer cells.

Asked if he is disappointed that it appears that key DNA evidence may be missing or unusable, Chompuchat said: "We expected this before".

A Thai court hearing the case of two Burmese men accused of murdering two British backpackers stalled on the second day of a three-month trial after a police officer failed to present what the defence says is key DNA evidence.

Key DNA-binding residues identified from crystal structure of mTBX3 are highlighted in red.

Unexpectedly, Nutlin-3 also mediated phosphorylation of p53 at key DNA-damage-specific serine residues (Ser15, 20 and 37).

Using the TCGA data sets of four cancers (3980 samples), they identified 718 genes that were mutually exclusive with six key DNA-damage response genes.

The invariant GGA core bases of the ETS-family profiles are consistent with the absolute conservation of two key DNA-contacting arginines in Helix3.