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Second, a higher proportion of singletons in the 5'UTR than in synonymous sites of protein coding regions (Table 2) implied that the effect of selection has kept deleterious mutations at low frequencies.
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Some of the new mutations that arise in the maize genome can be deleterious; although selection acts to keep deleterious variants rare, their complete removal is impeded by genetic linkage to favourable loci and by finite population size1,2,3,4.
Large N e means that a very small selection pressure can keep deleterious elements at low frequencies.
As DNA end joining would be detrimental to chromosome ends, it was though that Ku has to be kept away from telomeres to prevent deleterious telomere-telomere fusion.
To keep this deleterious capacity in check, the cell has evolved mechanisms to maintain tight regulatory control of copper storage and transport [ 1].
EPA kept approving "bad actors," deleterious pesticides, with far-reaching consequences not merely for honeybees but for all life.
Strongly deleterious mutations are expected to be kept at low frequencies by natural selection, whereas weakly deleterious alleles may be effectively neutral (Ohta 1973; Kimura 1983) and subject to the effects of genetic drift (Lynch and Gabriel 1990; Lande 1994; Whitlock et al. 2003).
I kept saying the environmental conditions in America are deleterious to all life, including human life.
In classical evolutionary computing, the recognition that most mutations were or are deleterious meant that mutation rates were kept low.
When a UV is identified, women are told that this result does not allow for concluding that a causal mutation was found; however, clinicians will be kept informed whether this mutation is reclassified as deleterious in the future.
Environmental considerations, on the other hand, dictate that the site should be far enough away from urban centres that noise and other deleterious effects on the population should be kept to acceptable levels.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com