Therefore, the FGF4/Erk pathway might be a regulator mechanism of the proposed "gate-keeper" function of Nanog for the differentiation of ES cells.
Furthermore, we provide a conceptual framework that consistently explains Nanog variability and a potential "gate-keeper" function of Nanog expression with respect to the control of ES cell differentiation.
Brat is expressed throughout Drosophila brain development and exerts an essential gate-keeper function in the binary switch between self-renewal and differentiation of neural progenitor cells.
Regarding the organisation of care, the DELIVER study aims to provide evidence about the referring system ('gate-keeper function' of midwives), role and responsibilities of midwives, collaboration with other care providers (e.g. continuity of care), and time expenditure of midwives.
Norway has a high rate of contacts to the OOH services because of the gate-keeper function for secondary care, in contrast to other countries, where the patients can choose between emergency departments and OOH services [ 6– 9].
The emerging model thus identifies the basal body/transition zone as a hub controlling access to the cilium, where ciliopathy proteins localized at this entry-point facilitate the selective entry of ciliary-bound proteins through a role in vesicle trafficking (entry-facilitator function) (23, 42, 45) and restrict access to the cilium to non-ciliary-targeted proteins (gate-keeper function) (39, 41).
This gate-keeper function differs from the entry-facilitator function for Cc2d2a identified by our work, in that the former is required to keep non-ciliary-directed proteins out of the cilium, whereas the latter is actively required for the entry of ciliary proteins.
A well-known issue in functional neuroimaging studies, regarding motor synchronization, is to design suitable control tasks able to discriminate between the brain structures involved in primary time-keeper functions and those related to other processes such as attentional effort.
The aim of this work was to investigate how the predictability of stimulus onsets in the baseline condition modulates the activity in brain structures related to processes involved in time-keeper functions during the performance of a visually cued motor synchronization task (VM).
14 Thus, the presence and function of primary care physicians are increasingly being recognised within an effective healthcare system especially through their gate-keeper role to the more expensive hospital care.
