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From this angle, Treg-oriented therapies should be especially useful in the prophylaxis of GvHD as Tregs keep tolerance to the matched host tissues but they can also react across MHC barriers and prevent the initiation of immune responses to host antigens, even when tissue injury after conditioning or infection is present.
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In a tearful tribute, Hamel's niece, Jessica Delporte, added: "After Charlie Hebdo I posted this phrase [on social media] 'Oh my God, let's keep our tolerance and discernment', never thinking I would have to apply that phrase to myself with so much force and conviction".
Remember your manners, keep your tolerance level high and forget your comebacks unless you've really been annoyed!
A novel annular reactor for kinetic studies at high temperature and flow conditions has been designed to keep eccentricity tolerances below 10%.
However, the radiation dose in these tissues should be kept below tolerance which means below the dose which creates clinically manifest severe damage.
Dose to organs at risk was kept below tolerance levels for all patients (these were near-to-maximum dose <12Gy for brain stem, <8Gy for optic structures, <12Gy for cochlea).
It is at these points that shared values and tolerance keep the team together.
Not surprisingly, multiple levels of tolerance keep fully functional NK cells in check.
The Americans were allowed to keep their zero-tolerance provision for abusive priests, making the rules for the church in the United States far more stringent than in most of the rest of the world.
How to keep traceability of tolerances during the design process?
A good tolerance allocation model should maximize component tolerances for a specified assembly tolerance to keep production costs low.
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