"If we keep tweaking this molecule, we'll be busy for life," said Hunt. "Sister chemicals are as bad, maybe even worse, than BPA".
More nonpolar residues in α2 would mean greater hydrophobic attraction, promoting assembly, whereas a higher net charge may keep the molecule hydrated, thus, it may allow axial sliding of collagen molecules in a bundle that is crucial for proper ordering.
The adjective cohesive is well chosen because it indicates that this energy is associated with the forces that keep the molecules close together in a condensed state.
Even if you enjoy a steady supply of food your entire life, you still rely on autophagy for another reason: to keep the molecules in your cells in good working order.
It allows molecules to enter the interstitial tumor space, by suppressing the lymphatic filtration making it possible to keep the molecules in the malignant cells.
Somehow, a cell must get all its proteins to their correct destinations and keep these molecules out of the wrong places.
Dubochet found a way to add water to the samples and freeze it so quickly that it formed a kind of liquid glass; this kept the molecules from collapsing without diffracting the electron beam.
(In nature, ice does not have this problem because it has a three-dimensional structure that keeps the molecules in the proper position).
An argument to explain that parasites would keep a molecule that allows them to be recognized by the host, and thus work as an avirulence effector, is that Avr proteins perform some essential function, and therefore must be retained [ 12].
Although it seems beneficial for every organism to keep a molecule with photolyase activity as Cry5 /6-4PhR (Todo, Kim, et al. 1997; Todo, Ryo, et al. 1997; Uchida et al. 1997; Kobayashi et al. 2000), this gene was lost independently in several vertebrate lineages.
