To compare correlations of transcripts from the low oxygen exposure experiment, we combined the control normoxia fish from the high and low energy feeding groups (n = 18), and the low oxygen-exposed fish from the two dietary groups (n = 18), to search for altered correlations in fish kept at suboptimal oxygen saturation for 120 days (data shown in Additional file 5, worksheet B).
However, we should keep in mind the suboptimal choice of the spoligotyping-VNTR genotyping scheme, which provided only a slight or no improvement compared to spoligotyping only.
Besides, one has to keep in mind that a suboptimal thyroid hormone state may affect well-being.
Given the toxicity-related death caused by cytokine storm with high levels of IFNγ [ 34], we thus chose the regimen of IL-2 at suboptimal dose in order to keep animal alive for analysis.
3 More recent estimates keep 35% as the overall impact of suboptimal dietary choices, but more specifically note that diet may be linked to as many as 70% of cases of colorectal and prostate cancer, 50% of cases for breast, endometrial, pancreatic, and gallbladder cancers, but only to about 20% of cases of lung, bladder, mouth, and esophageal cancers.
We should try to keep the dose low and sometimes even accept suboptimal images as long as they provide us with the necessary information.
During highly active anti-retroviral treatment (HAART), macrophages keep producing virus because tissue penetration of antiretrovirals is suboptimal and the efficacy of some is reduced.
They also asserted that, in uremic patients, oral iron is unlikely to keep pace with iron demand, rendering the response to erythropoietin suboptimal.
Furthermore, cells residing in the gut associated lymphoid tissue (GALT) [7], [8], the testis [9], [10] and the central nervous system (CNS) [11], [12] may keep producing virus despite the use of antiretrovirals, because drug penetration of these tissues is suboptimal.
This information will also inform decisions to keep or delete certain variables and will provide the evidence base for initiating the important dialogue necessary for modifying suboptimal - yet highly critical – variables for the purposes of surveillance, monitoring, evaluation or research.
