Under normal growth conditions, p53 is kept latent in various ways, e.g. by keeping it in the cytoplasm, by targeting it for proteasomal degradation, or by inhibiting binding to its DNA target sites [2].
It is likely that the elderly kept latent infection of M. tuberculosis for long years, and the age-associated decline in immune response caused development of active TB, while the younger patients developed active TB soon after initial infection (Tufariello et al. 2003).
I try hard to keep any latent theological concerns out of my work.
In a normal person the immune system (the T lymphocytes, those that mature in the thymus, in particular) keeps the latent viruses in check.
The activation of acute disease in immunocompromised patients and immunohistochemical data obtained on mice [ 59] suggest that under normal conditions both diseases are kept in latent form by the host immune system.
IGF binding proteins keep this molecule latent.
The gene product, LTBP4, belongs to the latent transforming growth factor beta binding proteins (LTBPs), which associate with TGFβ when secreted into the ECM and keep TGFβ in its latent form.
Interestingly, alcohol exposure in vitro also decreased the protein expression of Keap1, which itself is ARE-dependent and serves to keep Nrf2 in a latent but "ready" state in the cytoplasm as well as maintaining the levels of Nrf2 (Lee et al., 2007).
At NIPH, no total counts of reported syphilis cases are kept, but late latent probably represent a majority (more than 50%).
This scheme is proposed as a direct analogy to the control mechanism of PrrC which is kept in its latent state via the interaction with the associated RM system.
As Hill et al. [ 17] suggested, GASP1 may inhibit the propeptide proteolysis to keep the myostatin in a latent and inactive form.
