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Giannattasio et al. proposed that Exo1p (in competition with DNA polymerases that fill in the 30-base gaps) can expand the short gaps to ∼1 kb, triggering the G1/S checkpoint.
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In Pinaceae, inverted repeats larger than 0.5 kb could trigger plastomic isomerization, and retention of an isomer was species- or population-specific (Tsumura et al. 2000; Wu et al. 2011).
This variant is 61 Kb downstream from natural cytotoxicity triggering receptor 2 (NCR2), and its minor (risk) allele showed 4.4% enrichment among moderate CP patients when compared with healthy participants.
In vitro studies have shown that TTR aggregates interact with RAGE triggering nuclear translocation of NF-kB [ 11].
The authors also suggested that insertion of big (>100 kB) pathogenicity islands might trigger genome rearrangement processes in order to reach the ori-ter balance.
Actually, hypoxia both sustained (morbid obesity) and/or intermittent (OSAS) is acknowledged as triggering inflammatory pathways mediated by the transcription factor nuclear factor kappa B (NF-kB) and hypoxia-inducible factor 1 (HIF-1).
Tanshinone-1 induced more apoptosis by triggering increased loss of mitochondria membrane potential (MMP) and stronger activation of caspase-3 and caspase-9 in KB/VCR cells than in KB cells in a concentration-dependent manner.
TRAF6, together with Gab2 [ 149], triggers NF-kB, Akt and Jnk pathways.
The key signalling event, which is likely to be instigated by a mite-derived factor, closely mirrors that of the host response to LPS, potentially acting via a TLR to trigger NF-kB.
In addition, recent findings show a role for IAPs in metastatization as a XIAP/survivin complex would trigger NF-kB pathway leading to activation of cell motility kinases [ 43].
One the other hand, in a study lately published, Kim et al. reported that upregulation of miR-205 in KB oral cancer cells could trigger cell apoptosis.
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