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In view of the ubiquity of 'abnormal' karyotypes in cancers it is tempting to think that the cancer-specific karyotypic abnormality could be normal.
Complete loss or interstitial deletions of chromosome 5 are the most common karyotypic abnormality in myelodysplastic syndromes (MDSs).
Gene expression profiling and the identification of a number of unique mutations in leukemia cells may help discriminate among the heterogeneous outcomes observed both in patients with the same karyotypic abnormality and in patients with normal cytogenetics.
Seven patient samples (patients n. 104 110) carrying the t(15 17) translocations were selected based on karyotypic abnormality and sample availability.
The chromosome Ph was the only karyotypic abnormality.
Deletions of 5q occur in approximately 12% of MDS patients and represent the most common karyotypic abnormality in MDS.
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Clonal karyotypic abnormalities (⩾2 abnormal cells in metaphase) were present in 46% of patients, including interstitial deletion of chromosome 5q31.1 alone in 11 patients.
However, most elderly individuals have an intermediate cytogenetic risk, which the MRC AML11 trial defined as the presence of unfavorable, non-complex karyotypic abnormalities as well as the presence of normal karyotype.
Of 165 fetuses, 3 (1.8%) had karyotypic abnormalities.
Kliman HJ, French L. Trophoblast inclusions are associated with karyotypic abnormalities.
Survey of immunophenotype, French-American-British classification, frequency of myeloid antigen expression, and karyotypic abnormalities in 210 pediatric and adult cases.
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