Exact(3)
At low traffic density k, driver's attention is not high, and some discretionary behaviors may be operated.
For example, it was pointed out that the subsequent driver mutations appear faster and faster and the cumulative time to have k driver mutations grows with the logarithm of k [ 42].
It follows that the probability of mutation after d divisions is: (4) For multiple (k) genes: (5) The above equation calculates the probability of a single cell accumulating all k driver mutations after d divisions.
Similar(57)
Since we don't know for sure, we'll just do what we used to do on TV and make it up: "And nobody got hurt!" Happy Birthday: The King, driver Richard Petty, who won 200 races.
Liz King, the driver, saved our lives.
Equation [8] with six k rate-limiting driver pathway mutations will be subsequently used for further analysis because of a better conceptual fit with the idea that regulatory pathways rather than specific single genes are altered in cancer [ 5].
In the case that resident tumor cells are subject to a density limitation, the effect of this density limitation on tumor dynamics depends strongly on the product of the carrying capacity K and the driver mutation rate u.
(8) Equation [8] is an algebraic representation of an analysis published earlier [ 1] for a probabilistic model of colorectal cancer that starts from birth and ends when the first stem cell (out of many at risk) accumulates a critical number of k rate-limiting driver mutations (Fig 1).
There was no significant difference between hUCP3 expresser line K compared with +/dilp2-GAL4 driver control, although the driver caused a small but significant change in dilp2 and dilp5 (but not dilp3) gene expression (Fig. 6; dilP2, P = 0.013; dilP5, P = 0.016 by one way ANOVA).
These factors are the number of divisions (d), the number of stem cells (N × m), the number of critical rate-limiting driver pathway mutations (k), and the mutation rate (u).
"Sadly, the 4x4 has become an acceptable alternative to Mercedes or BMW for the pompous, self-important driver," Mr. King told The Daily Mail in 2004.
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