There is also the issue of acceptability and provenance, cf. [16]: since their decisions might be life-critical, medical professionals will not accept automatic systems, even with high precision, which cannot justify the rationale for the automatic decision.
This justifies the rationale where auxiliary RNAi factors are also integral part of gene silencing apparatus.
Furthermore, our previous experiences with myo-inositol justified the rationale of this study.
A comprehensive evidence base from existing systematic reviews of prediction models was used to support and justify the rationale for including and illustrating each checklist item.
Firstly, the findings justify the rationale for including intangible costs in economic evaluations of stillbirth by revealing their potentially significant contribution to the total costs.
16, 17 The onset of CRC is triggered by a well-defined sequence of genetic alterations that form the etiological basis of the adenoma-carcinoma sequence hypothesis and justify the rationale for CRC screening.
These trials challenged conventional wisdom, which justified the rationale for 50 Gy in 25 fractions, namely that cancers in the breast are less sensitive to changes in dose per fraction than the dose-limiting surrounding normal tissues.
Forty three presented sensitivity and specificity, 27 justified the rationale for cut-off points, 22 presented a positive predictive value, 19 presented a negative predictive value, and 26 made some attempt to indicate the percentage of the population that would need clinical follow-up or testing if they scored as "high risk".
As indicated in Figure 1, the variants associated with SLE, RA, IBD, and type I diabetes locate relatively close to each other, which further justify the rationale of considering other immune disorders in proband's relatives while selecting an individual for genetic testing.
The mechanisms of heart failure in children are often radically different than those seen in adults and justifying the study rationale for the use of an adult heart failure medication to children can be challenging.
