The goals of this Commentary are to explain the origins of risk compensation behavior in risk homeostasis theory, to reframe risk compensation as a testable response to the perception of reduced risk, and to assess the methodological rigor and ethical justification of study designs aiming to isolate risk compensation responses.
Justification of study size is hardly provided, especially when a Rasch model is planned for analysing the data in a 2-group comparison study.
Disease outcomes should be defined by reference to established diagnostic criteria or justification of study-specific criteria, if such are employed.
Even if guidelines have also been recently published for PRO based studies [ 20, 21], the reporting of such studies often lacks mentioning the justification of study size and its computation.
The criteria examined by the critical appraisal tool included appropriateness of study design, representativeness of sample frame, selection process, analytical methods, completeness of description of methods, internal consistency of results, completeness of discussion and justification of study conclusions.
Yet the consistency of the observed associations support the generation of new hypotheses and justification of future studies.
If cabozantinib does not demonstrate an overall survival benefit in this pretreated patient population, justification of additional studies in earlier stages of prostate cancer will be very difficult.
This study provides important justification for studies of immunotherapeutic studies in patients with early/minimal/no evidence of disease.
This revealed that 59% used a review proforma, 52% were double-blind and that correct justification of the study conclusions was the most important feature for study design in 80% of the journals.
There was growing frustration among the panel concerning both the role of higher education institutions in promoting music and the continued justification of musical study from a non-musical perspective.
