Indeed, when the high court considered Roberts's case it made the astonishing assertion that, to people in Haringey, "the possibility of being subjected to a random search must seem a justifiable price to pay for greater security and protection from indiscriminate use of weapons".
Similarly, the economically justifiable price of the routine programme increases with t.
The indirect effect (and the duration of protection) can have a substantial impact on vaccines' economically justifiable price [ 16].
If it is assumed that gonorrhea does not increase the risk of contracting HIV, the economically justifiable price would only be $13.20/dose.
This justifiable price difference between both vaccines estimated in the present study is slightly different from that found in other studies [ 31].
The economically justifiable price was additionally calculated taking into account income lost, but results are also presented without any impact on productivity.
The exclusion of income lost as a result of gonorrhea sequelae only decreased the economically justifiable price by $1.20 per dose.
Also, if the cost of new antibiotic treatment (for the same efficacy) was twice as high as today's, the economically justifiable price of the vaccine would be $27 per dose; similarly, if the cost of new antibiotic treatment was 5 or 10 times as high as today's, the economically justifiable price of the vaccine would be $31 and $36 per dose, respectively.
From the societal perspective, without considering the vaccine's effect on meningococcal disease, the economically justifiable price per dose for an effect on gonorrhea was $26.10 (95% CrI, $9.10 $57.20), which translates into incremental (to meningococcal program) vaccination costs of $148 million.
If the disutility associated with infertility and chronic pelvic pain was assumed to last for 20 years instead of 10 years, the economically justifiable price would be $32.70 per dose.
Key outcome measures were reductions in gonorrhea and HIV infections, reduction in quality-adjusted life-years (QALYs) lost, and the economically justifiable price assuming a willingness-to-pay threshold of $75,000 per QALY gained.
