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Free energy minimization allowed the construction of a phase diagram with axes the junction functionality and the composition.
The influence of chain entanglements and junction functionality on the chemo-mechanical behavior of hydrogels is addressed based on our simulation.
The phase diagram shows that an increase in the junction functionality leads to an expansion of the region of spheres at the expense of cylinders, and to an eventual elimination of reverse spheres in favor of reverse cylinders.
While earlier studies mainly focused on the relevance of transmembrane adhesion molecules for tight junction functionality, there is a growing body of evidence pointing towards a critical role of actin cytoskeleton dynamics in modulating the permeability of the BBB [11] and other endothelia [12], [13].
This causes loss of tight junction functionality and increased intestinal permeability.
A proinflammatory intestinal cytokine environment affects tight junction functionality and subsequently increases intestinal permeability [ 12, 29].
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We find that ν ∼ 2 4, at room temperature, for DGEBA-based epoxies including SU-8 and DGEBA-amine networks, over a range of network junction functionalities and V*.
Finally, a microinjection/dye-transfer assay, employed to determine gap-junction functionality, clearly demonstrated that the cells were functionally coupled, albeit to varying degrees, in differentiated and undifferentiated phenotypes.
When inflammation occurs, like at weaning, the epithelial barrier and tight junctions functionality are impaired and the ability of the enterocyte to absorb nutrients decreases.
Specifically, we demonstrate that CA and RC surfaces are promoting cardiac cell growth, enhancing cell connectivity (gap junctions) and electrical functionality.
To describe precisely the chemo-mechanical coupling behavior of hydrogels, a general form of free energy density function is presented by considering chain entanglements and functionality of junctions.
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