Nualart-Marti, A., Solsona, C. & Fields, R. D. Gap junction communication in myelinating glia.
We have now used a cellulose-coated polystyrene inducing the same cell behaviour to analyse the gap junction communication between aggregated cells.
When these bioengineered 3D tissue grafts are transplanted onto damaged hearts, gap junction communication between graft and host is likely critical for synchronized beating and functional improvement.
Gap junction blockers (GJBs) include various chemicals that impair gap junction communication, disrupt oscillatory neuronal activity over a wide range of frequencies, and decrease epileptic discharges.
Here, we report that the expression of numerous paracellular junction genes was decreased in iron-loaded hepatocytes, leading to increased cellular permeability, increased baculovirus-mediated gene transfer, and decreased gap junction communication.
Although the cell population(s) responsible for generating this activity have not been characterized yet, the evidence suggests that they are neurons, as the spontaneous contractions are abolished in nerve-free hydras43 and drastically reduced when gap junction communication among neurons is inhibited44.
"Carotenoids also may be directly anticarcinogenic by several other mechanisms, including improved gap junction communication, enhanced immune system functioning, or antioxidant scavenging of reactive oxygen species; this may inhibit cellular dysregulation or DNA damage," they wrote.
These studies indicate that knock-in α3 connexin enhanced intercellular gap junction communication may provide a potential way for promoting lens transparency and suppressing cataract formation by rescuing the deficiency of intercellular gap junction communication [25], [27], [28].
Each gap junction communication channel is made of two hemichannels (commonly called connexons), one each from the apposing cells.
Results which further support Cx36 playing a significant physiological role in intra-neuronal gap junction communication in intact networks.
The area stained with Lucifer yellow but not with Rhodamine red was used as an index of gap junction communication.
