Philip Landrigan, former director of the Children's Environmental Health Center at New York's Mount Sinai Hospital, recommends a hybrid approach: the judicious creation of new birth cohorts and/or the recruitment of new mother infant pairs into selected existing cohorts.
Small market sizes are further exacerbated by the appropriate principles of antibiotic stewardship, which lead thought leaders to advise judicious use when new antibiotics become available, such that sales of new antibiotics typically under-perform relative to expectations, particularly during the first years after market entry.
These new, judicious exhibitions, though, may yet tell other stories.
The great challenge for 2011 and beyond is to find that new judicious equilibrium.
In this context, Joseph Lelyveld's judicious and thoughtful new book, "Great Soul: Mahatma Gandhi and His Struggle With India," seems almost eccentric, devoted as it is to explaining the evolution of a social and moral philosophy that, 60 years after the end of the British Raj, has lost the attention of the nation it once enthralled.
I argue that a judicious combination of new and old approaches is the best way to advance our understanding of higher brain function in health and disease.
The overall message derived from the introduction of mesostructured zeolites and additional messages are continued in the collection of articles contained in Ref [32] is that by judicious design of new solid catalysts, more efficient ways can be found for processing nonrenewable feedstocks.
"So we expect more judicious review [of new projects by developers] going forward".
Finally the report insists on the judicious use of new technologies.
Targeted and judicious use of newer fluoroquinolones in selected CAP patients, including those with infection owing to highly-resistant pneumococci, or following treatment failure with first-line regimen, will minimize the emergence of bacterial resistance to the entire class and maintain class efficacy (Heffelfnger et al 2000).
