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Initial analyses provide a judgment of sample quality, revealing the potential presence of aggregation, the overall extent of folding or disorder, the radius of gyration, maximum particle dimensions and oligomerization state.
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To improve the judgment of transferability, the sample setting, data collection and analysis process were carefully described.
First, we completely agree that for a thorough judgment of any assay samples from clinically well-defined patients are necessary.
Several factors that may affect the accuracy have been recognized, such as subjective judgment of the examiners, sampling techniques, and islet purity.
The sample closure at 11 was reasoned by a judgment of a sufficient, representative sample size.
To ascertain the reliability of the judgment, a random sample of 10% of subjects' records were assessed independently by members of the expert panel.
In 11/47 4G8 samples, the cut-off definition did not match the overall pathology judgment (8 samples with 4G8 positivity ≤2.5% had an overall pathology judgment of abnormal, and 3 samples with 4G8 positivity >2.5% had an overall pathology judgment of normal).
Furthermore, in this type of sample, interviewers have to use their judgment in selecting respondents.
By designing a series of Boolean logic operations, we could logically make judgment of the compositions of the samples on the basis of visual output signals.
Periodic independent auditing of sample cases is needed to validate the judgments being made in-house about practice standards and adequacy.
An alternative to probability sampling is judgment sampling, in which selection is based on the judgment of the researcher and there is an unknown probability of inclusion in the sample for any given case.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com