Additional file 1: Number of joints: symptomatic, punctured and according to the diagnosis after arthrocentesis.
On the other hand, many COMP-MED patients showed persistent aberrant hip development, and ended up with deformed and sometimes subluxated hip joints, which may keep the hip joints symptomatic, even at adolescence.
The MSUS examination was divided in two parts: a) mandatory joints b) symptomatic joints.
The purpose of this retrospective study was to assess the diagnostic performance of the 3D TSE SPACE sequence, as compared to routine 2D TSE sequences, for evaluating the menisci, anterior cruciate ligament (ACL) and cartilage of the knee joint in symptomatic patients at 3 T.
This study indicates that the level of IL-6 is increased in joints with symptomatic cartilage defects or OA compared to healthy joints.
Levels of IL-6 comparable to those reported here were previously shown in the synovial fluid from healthy [ 10] and OA [ 10, 12, 56] joints; however, only limited data were available on IL-6 levels in joints with symptomatic focal cartilage defects.
However, the presence of IL-6 in joints with symptomatic cartilage defects has not been evaluated until now.
Many of the aspirations were carried out under US guidance, especially when small joints were symptomatic or when little synovial fluid was present.
Several pro-inflammatory, pro-angiogenic and pro-repair cytokines were elevated in joints with symptomatic cartilage defects and/or osteoarthritis, although different cytokines were elevated in synovial fluid compared to tissue or cells.
Information collected from each proband, their siblings, spouses, and siblings of spouses included date of birth, sex, ethnic background, education status, occupation, other joints affected with symptomatic OA, age at joint replacement(s), and site(s) of joint replacement.
