Importantly, psi-tGC-NPs show the high accumulation at the arthritic joint sites in collagen-induced arthritis (CIA) mice.
Meulenbelt et. al. identified three components that reflected radiographic OA at different joint sites.
Further, because the study participants were selected on the basis of familial hand OA, they may have had greater correlation of OA among joint sites than individuals without so clearly a familial etiology of OA.
There is strong evidence for association with OA at specific joint sites for each of these biomarkers [12], [17], [25], [37], [38], [39] but association with total body burden of disease has not been attempted previously.
Disease in other joint sites was common.
*These joint sites were examined in 68 free-range and 36 confined pigs.
Approximately three quarters of respondents reported ≥ 2 joint sites affected by OA.
In addition, the different joint sites can have different structural and symptomatic appearances [ 21].
However, specific joint tissues fail to differentiate appropriately at the joint sites.
Probands (ages 40 70 years) and their siblings had OA at multiple joint sites of the hand or in two or more of the following joint sites: hand, spine (cervical or lumbar), knee or hip as described previously.
This might explain the uncertain estimates and large confidence intervals noted at a few of the joint sites.
