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R.A. has significant health consequences beyond joint destruction.
Rheumatoid arthritis (RA) is a chronic heterogeneous autoimmune disease characterized by progressive joint destruction.
Synovitis, which is secondarily induced, is related to joint destruction and OA progression [19].
Joint pathogenesis involves inflammation of the synovial lining, with the potential to cause joint destruction.
In latter stages joint destruction, bone union and malalignment may occur (Fig. 2).
FGF8 induced joint destruction in vivo.
All six patients had severe joint destruction.
Repeat injections enhance chronicity and joint destruction.
Treatment with Rac1 peptide did not protect against joint destruction.
Patient RA10 had long disease duration subsequently severe joint destruction.
Inflammation and joint destruction were examined by histology and radiology.
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