Neuronal mechanisms involved in arthritic pain are the peripheral sensitization (sensitization of primary afferent fibres supplying the joint) and central sensitization (sensitization of spinal cord neurons).
Behçet's disease (BD) is characterized by oral and genital ulceration and is complicated by eye, skin, joint and central nervous system lesions.
This group of illnesses includes familial cold urticaria, Muckle-Wells syndrome, and CINCA (chronic infantile neurologic, cutaneous, and articular) and represents a continuum of clinical manifestations of inflammation in the skin, joint, and central nervous system.
It is likely that the host has an inappropriate immune response involving human tissues such as the heart, joints, and central nervous system.
The resulting accumulation of unprocessed or partly processed GAGs dermatan sulphate, heparan sulphate, keratan sulphate and chondroitin sulphate in lysosomes causes progressive damage of affected tissues, including heart, respiratory system, bones, joints and central nervous system [1].
Production of autoantibodies, tissue deposits of immune complexes and inflammation in kidneys, skin, joints and central nervous system are hallmarks of SLE.
Lyme disease is a multisystem infection, with inflammatory complications that commonly affect the skin, joints, and central nervous system in humans (6 ).
Pain in OA, like other chronic pain conditions, is a complex integration of sensory, affective and cognitive processes that involves a number of abnormal cellular mechanisms at both peripheral (joints) and central (spinal and supraspinal) levels of the nervous system.
Lyme disease is frequently a multisystem infection, commonly affecting the skin, joints, and central nervous system in humans [ 2, 3], yet at other times the symptoms are restricted to the skin.
Behçet's disease is a multisystem disorder that is characterized by oral and genital ulcers, and mucocutaneous, ocular, joint, vascular and central nervous system involvement.
The analgesic properties of NSAIDs for joint pain are well known and clinical improvement has been reported with many different compounds [ 37] Robenacoxib preferentially inhibits the COX-2 enzyme which is involved in the pathophysiology of joint pain and central sensitization [ 2].
