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Furthermore, joint molecules (JMs) containing a dHJ intermediate are detected at higher levels during DSB-induced interhomolog recombination in sgs1 diploid cells than in wild type (Bzymek et al. 2010).
Persistent JMs containing a single HJ (sHJ) connecting the ectopic sequences were identified in the mus81 yen1 mutant, and their formation, as well as generation of CO products, was dependent on RAD1 (Mazon et al. 2012; Mazon and Symington 2013).
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TH: You need to feel structured around that... JM: Contained.
The juxtamembrane domain JM-a, but not JM-b, contains a cleavage site for the tumor-necrosis-factor-α-converting enzyme (TACE).
The use of chimeric IA-2 constructs and competition studies using synthetic peptides has previously identified two distinct epitopes within the IA-2 JM domain contained within IA-2 regions 611 620 (JM1) and 621 630 (JM2) [ 8].
EUCAWOOD unigenes containing ESTs from Jm or Mj libraries produced matches with 57 and 47 different protein families, respectively, including only five families common to both Jm and Mj libraries.
The JM-A segment contains three clusters of positively charged (Arg and Lys) residues that have been suggested to bind to negatively charged lipids [16].
It has previously been suggested that antibodies to the JM domain bind linear epitopes, on the basis that these can be represented by short sequences of JM amino acids contained within, for example, synthetic peptides [ 8].
Cells of E. coli JM 101 and PAO1 (106 each) and PP9 and E. coli JM 101 (106 each) were inoculated in shaking flask containing Tris minimal media with 5 mM BA.
The JM region from FGFR3 binds to the acidic membrane containing PIP2.
In addition, the unstructured JM region of the wild-type Neu TM JM peptide was found to be bound to acidic membranes containing the phosphoinositide, PIP2.
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