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Approval for use of the specimens was given by the TREAT in JIA study oversight committee.
In this study, we used whole blood gene expression profiles to determine whether we could predict therapeutic response in children enrolled in the TREAT in JIA study.
We used an independent cohort of patients from Oklahoma to validate the statistical methods used to analyze the TREAT in JIA study samples.
The results of the present study were similar to those from a JIA study conducted in the USA and Europe [ 16].
The similarity of the inclusion criteria between the present study conducted in Japan and the Western JIA study [ 16] allows for comparison of the results.
Under any circumstances, although the TREAT in JIA study may have experienced some recruitment bias in favor of RF+ patients (35% of the TREAT in JIA study subjects were RF+), it appears to be feasible to group RF+ with RF− patients in future attempts to develop expression-based predictive models or assays.
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Mr. Jia studied the fossils to piece together how hominids in the region evolved and supported the theory that modern Chinese could be traced from them.
In 2012, Gao and Jia studied the boundedness of commutator ([b,H_{Phi }]) of Hausdorff operator with central BMO function in Lebesgue space, Morrey-Herz spaces, and Herz spaces in [9].
No serious new onset/worsening of psoriasis events were reported in JIA studies.
Indeed, all four patients with systemic JIA studied here had a very low proportion of TReg in peripheral blood.
Therefore, placebo data based on a meta-analysis from previous JIA studies were used as one of the prespecified comparators.
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