Insulin injected by jet injection displays a specific cone-like dispersion pattern in the subcutaneous tissue with a relatively large surface area (1, 2).
To establish skin penetration depth following low-volume jet injection, one rabbit was injected at 6 different sites with a 1% India ink solution.
To establish optimal injection conditions for low-volume jet injection, two rabbits were injected at a total of 15 sites per rabbit with pHCMVIE1-luciferase and euthanized 48 h later.
In this study, the pharmacodynamic and pharmacokinetic profiles of the rapid-acting insulin analog aspart, injected by either jet injection technique or by conventional insulin pen, were compared.
Low-volume jet injection deliberately limits the volume of the injected solution and is utilized to target delivery to small tissue areas [ 2].
Taberner A.J., Hogan, N.C., Hunter, I.W., "Real-time-feedback-controlled Needle-free Jet Injection Using Linear Lorentz-force Motors," Journal of Medical Engineering Physics, 34 1228-1235, 2012.
The crossflow exhibits considerable swirl at the location of the transverse jet injection.
Among needle-free drug delivery methods, jet injection is an old strategy with great potential not yet completely disclosed.
In the present work, we study foam jet injection into gypsum slurry at rest and in cross-flow.
US Patent 8,821,434, Hunter, I.W., Taberner, A.J., Hogan, N.C., "Delivery of a Solid Body and/or a Fluid Using Linear Lorentz-force Actuated Needle-free Jet Injection System," September 2, 2014.
Low-volume jet injection is a simple, effective methodology for intradermal DNA immunization.
