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Coadministered epidural fentanyl infusions were more than three times more potent than IV fentanyl infusions, suggesting a predominantly spinal mechanism of opioid action under these study conditions.
At 48 h postdose, significantly more single-dose EREM patients (13%) than MS patients (2%) had required no IV fentanyl (P < 0.01).
Group A: Subjects received IV fentanyl 1 mcg/kg as a titration dose and propofol 1 mg/kg followed by propofol 0.5 mg/kg if needed (n = 20).
Patients were randomly allocated to one of the two groups: 1. Group A: Subjects received IV fentanyl 1 mcg/kg as a titration dose and propofol 1 mg/kg followed by propofol 0.5 mg/kg if needed (n = 20). 2.
Group B: Subjects received IV fentanyl 1 mcg/kg as a bolus dose and a titration dose of midazolam 0.1 mg/kg and 0.1 mg/kg if needed (n = 20). .
INTERVENTIONS: Patients were randomized to receive either intravenous (IV) remifentanil (0.5 microg/kg/min for induction and intubation, with the infusion rate decreased to 0.25 microg/kg/min after intubation) or IV fentanyl (administered according to anesthesiologists' usual practice) as the opioid during surgery.
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Patients were given placebo (saline) or midazolam (5 mg im) 30-60 min prior to surgery, and then either placebo, oxymorphone (1 mg iv), or fentanyl (100 micrograms iv) 3-5 min prior to a standardized anesthetic technique.
Postoperative analgesia was initiated upon emergence from general anesthesia and maintained using IV opioids (fentanyl, meperidine, morphine, or hydromorphone) administered as patient-controlled analgesia (PCA) and/or continuous infusion depending on the postoperative status of the subject.
A careful review of the operative record failed to show any such administration, and she had only been given IV midazolam, fentanyl and cefazolin.
Small doses of midazolam (e.g. 1 - 2 mg IV) and/or fentanyl (e.g. 50 - 100 mcg IV) may be given to "smooth out" induction.
In an experimental study, the cardioprotective effects of IV-administered fentanyl using a model of myocardial ischemia-reperfusion injury associated with pharmacologically induced central sympathetic over activity were investigated.
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