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In conclusion, our results suggest that the major impact of RA on osteoclast biology in vitro is its substantial effects on precursor cells.
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Control of abscission has been an important agricultural concern because of its substantial effect on crop yield and quality.
In addition to its substantial effect on morbidity and mortality, HF is one of the most costly chronic diseases in developed countries.
Despite its substantial effect on patient outcomes and utilization of resources, few registry studies (Lindahl et al. 2005, 2006, Gjertsen et al. 2007) and single-center studies (Wu et al. 1999, Sarvilinna et al. 2004) have examined the factors associated with of periprosthetic fractures after THR.
However, the measurement of even basic quantities like the clustering coefficient ϕ for epidemiologically relevant contacts has yet to be attempted at a large geographical scale, particularly in non-household contexts, and we suggest that this could be an important measurement to make given its substantial effect on predicted outcomes.
The inhibition by ruthenium red of Ni2+-evoked Ca2+ signals need not reflect an action at PM RyR, because ruthenium red is membrane-impermeant and its most substantial effects on RyR appear to be mediated by binding to its cytosolic surface (177).
Additionally, PET studies demonstrated that Mn produces its most substantial effect on the nigrostriatal dopamine system not by producing its degeneration, but by disrupting the capacity to release dopamine.
Expander for such systems is a key component and its performance has substantial effects on overall system efficiency.
The interaction between IgE and allergen is a key event at the initiation of an allergic response, and its characteristics have substantial effects on the clinical manifestation.
The bilateral trade brought practical attribution to tariff transitions, and its substantial volume effects are ascribed to non-tariff cost shrinkages.
Solid solution strengthening can play a very important role in the performance of heat resistant steels, not only because of its substantial strengthening effect as such, but also because of the fact that the effect that solid solution strengthening is, by definition, time independent.
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