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The second important finding concerns amplification of the HER2 locus, which can be split into two subsets: (a) narrow amplicons (86 kb in its smallest form) that centered around HER2 and that comprise 6 to 10 genes, of which 4 showed recurrent overexpression, and (b) a large amplicon (1.1 Mb) starting centromeric to HER2 and extending telomeric to the TOP2A gene.
By dividing both the top and bottom of the fraction by the GCF, you should be able to simplify the fraction to its smallest form.
If the numerical constants have like factors, divide the constant in the numerator and the constant in the denominator by that like factor to reduce the fraction to its smallest form: 8/12 = 2/3 If the constants in a rational expression do not share like factors, they cannot be simplified: 7/5.
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