These chaperones function by binding to the enzyme and stabilizing its fold, allowing it to reach its site of activity, i.e. the lysosome.
The fundamental requirement of any new molecule is that it is able to reach its site of action in pharmacologically meaningful quantities, at doses which are generally safe and tolerable.
The carrier transports the drug to its site of action and releases it at the target site.
YouTube says it has been working hard to clear its site of such videos.
Early Detection After cancer has escaped from its site of origin, the ability to cure it plummets sharply.
CERT mediates the non-vesicular transport of ceramide from the endoplasmic reticulum (ER), its site of synthesis, to the Golgi complex, where it is converted into sphingomyelin (SM).
Protect Marriage Maine scrubbed its site of that statement fairly quickly.
Near Chatham, N.J. writer visited the Great Swamp National Wildlife Refuge, which was recently threatened by the possible erection on its site of a jetport.
The most common mutations disrupt the movement of C.F.T.R. from its point of origin to its site of operation and cause a severe and ultimately fatal disease.
This program, and its site of implementation, constitute our case study for this research.
ABC News has an un-embeddable video on its site of the bag streaking across.
