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Preventing the accumulation of SOD1G93A in the JUNQ by enhancing its sequestration in an insoluble inclusion reduces the harmful effects of aggregation on cell viability.
But CO2-sequestration technology is young: Problems remain with both the extraction of carbon from fossil fuels and its sequestration in underground aquifers.
The Plk4-mediated phosphorylation of the Hand1 transcription factor inhibits its sequestration in the nucleolus.
In our data, the presence of untranslated FGF2 mRNA after 3 h of hypoxic stress (Fig. 4B) could be explained by its sequestration in stress granules.
In resting cells most of the NF-κB remains inactive due to its sequestration in the cytoplasm by a group of inhibitory proteins known as inhibitors of κB (IκB).
ST and nicotine treatment also resulted in induction of Bad and Bax phosphorylation, increased the association of Bad with 14-3-3ζresulting 14-3-3ζresulting 14-3-3ζresultinglasm of head and neck cancer cells, thus blocking its pro-apoptotic function.
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These observations suggest that mutations in p53 may lead to its altered status and expression pattern in human breast carcinoma and is associated with its sequestration into heterochromatin resulting in its compromised activity.
First, we showed that Rab4b is mainly located with GLUT4, in its sequestration compartment and in TfR containing endosomes.
Modifications in Gln3 that abolished its ability to associate with Tor1 and diminished its cytosolic sequestration in nitrogen-rich medium, abolished the Gln3 localization response to rapamycin but did not compromise its response to nitrogen limitation (Rai et al., 2013).
This protein plays a pivotal role by enabling binary cell fate specification events to occur as a result of its asymmetric sequestration in post-mitotic neurons [ 28, 88, 90], How Numb exert its inhibitory function on Notch signalling remains poorly understood.
Altogether, our results documents Rab4b as the first Rab protein which co-localize in adipocytes with GLUT4 in its sequestration compartments which is modulated in diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com