Sentence examples for its pivotal function from inspiring English sources
Markedly, mouse studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport.
The involvement of this nigrostriatal dopaminergic pathway in Parkinson's disease, being subject to neurodegeneration, and in drug addiction, demonstrates its pivotal function in striatal physiology.
The evolutionary origin of its pivotal function has remained enigmatic and the discovery of two p53 siblings in vertebrates p63 and p73 further added complexity to this question because of their high functional diversity.
The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport.
The functional connection of DRIL1 to both Rb/E2F1 and p53 tumor suppressor pathways, as well as its pivotal function in promoting either cellular proliferation or growth arrest, implies a tight and finely tuned regulation of DRIL1 activity and binding affinities.
Its pivotal function in embryos and stem cells explain why its integrity is crucial in the avoidance of cancer.
The impact of genetic variations in Tat exon-1 on its pivotal functions is apparent.
The VFT2 domain is totally conserved within each of the two major BvgS types, indicating its pivotal role for the function of the protein.
It was first described in 1985 as a bladder tumour antigen (Banchereau et al, 1994) but this was largely overlooked when subsequent investigation revealed its pivotal role in B-cell function, where ligation with CD40 ligand (CD40L or CD154) expressed on activated T-helper cells stimulates cell maturation, proliferation and immunoglobulin class switching.
Taking into account that POP2 coding sequence is thought to be present as a single copy in Arabidopsis genome [ 25, 34], its prominent expression level suggests a pivotal function of GABA-T in GABA accumulation upon NaCl treatment.
PINK1 seems to have a pivotal function in organellar QC; it recruits PARKIN to impaired mitochondria, which targets them for mitophagy, and thereby promotes the removal of defective mitochondria.
