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The influence of the ureter is indispensable for the development of the metanephric excretory tubules, for, if the ureter fails to develop or, in its outgrowth, stops short of reaching the kidney-producing mesenchyme, no kidney develops.
Considering its cellular localization in phloem companion cells of the nodal vascular anastomoses, the asparagine from AS1 reactions in these cells is apparently transported to sink organs, such as axillary buds, for its outgrowth and development (Fig. 2).
This restoration indicated that GREM1 antagonizes BMP4 in the mesenchyme surrounding the nascent ureteric bud, which enables its outgrowth and invasion of the metanephric mesenchyme.
We previously established that Grem1, which is expressed by the mesenchyme surrounding the ureteric bud, is required to initiate its outgrowth [17].
In an attempt to gain further mechanistic insights into the inhibitory role of BMPs in the formation of the ureteric bud and initiation of its outgrowth, Bmp4 was genetically inactivated in Bmp4Δ/f mouse embryos carrying a tamoxifen-inducible Cre recombinase transgene (Bmp4Δ/Δc, TMCretg/+, Figure 1A, 1B) by injecting pregnant females with tamoxifen between embryonic day E8.75 E9.5.
The capacity of a tumour to induce new blood vessel formation is of key importance for its outgrowth and spread.
Similar(51)
"The pharynx and its outgrowths," reads another.
And then, out of all proportion to the rest of this half-timbered snooze of a town, the grandiose theatre and its outgrowths, now with added bombastic tower so that you can lord it over the sleepy Warwickshire environs.
It celebrates her early work in Calcutta's slums and credits her order and its outgrowths with providing "effective help to the poorest of the poor in a number of countries".
Explant of Brn3c containing retina in Brn3b −/− mutant mice has remarkable recovery in the neurite outgrowth, demonstrating its growth promoting function.
Radio and its digital outgrowth, podcasts, have superseded, in creativity and intimacy, Long John Nebel's greatest efforts to sell tall tales about his encounters with extraterrestrial beings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com