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The cell preserves its normal functional state and reaction to microenvironment stimuli, so that if the therapeutic protein is not needed at a particular period in time, the transfected cell may decrease the mRNA of the transgene by intracellular posttranscriptional mechanism regulated stability and the half-life of mRNA and thereby prevent protein production [ 151].
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The edit encoded by the donor DNA could be anything — it could be the normal, functional version of a gene; it could be a mutated sequence; it could even be an entirely new sequence foreign to that species.
Our data suggest that FGF21 is an inducible stress-sensing hepatokine, and its expression is associated with the loss of normal functional capacity of hepatocytes due to pathogenic processes.
In a similar study carried out in Saudi Arabia, 17 kidney transplant patients with normal functional ability and six with impaired but stable renal function were examined 1 week before, weekly during, and 1 week after the Ramadan fast (Abdalla et al, 1998).
PTPases contribute to the return to a normal functional state by dephosphorylating the receptor PTK; this is a major function of the receptor-like PTPases.
Group 3: 41 patients with anatomically and functionally normal coronary arteries as assessed by angiography and with normal functional tests (CFR ≥ 2.5 after intracoronary infusion of acetylcholine and adenosine) (Fig. 1 ).
Anti-inflammatories: if you are unable to carry out normal functional activities without significant pain, then a course of anti-inflammatories may be appropriate.
The effect of weakness in a particular muscle group depends on the normal functional role of the muscle and the degree to which force fails to develop.
Our findings necessitate reconsideration of many of the normal functional activities of different organs and of disordered fluid dynamics in the setting of disease, including fibrosis and metastasis.
The epitope was unavailable in cells expressing normal functional surface receptors.
Power dissipation during testing is more than twice compared with normal functional mode.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com