Sentence examples for its n-oxide from inspiring English sources

An intramolecular oxidation of 490 through its N-oxide forms 4-piperidone 491, an intermediate in the total synthesis of the alkaloid -decinine 492 (Scheme 162).

The aim of this study was to develop a simultaneous determination method for voriconazole (VRCZ) and its N-oxide (VNO) in human plasma and to apply it to clinical samples.

Dibenzo(b,f - 1,4,5 -thiadiazepine(III) and its N-oxide(IV) result in an electrolytically intact solution if the solution is made alkaline.

Modification of lead compound 7 by transformation of its N-oxide 6 6 biaryl ring system and fused aromatics produced a series of non-basic fXa inhibitors with excellent potency in anti-fXa and anticoagulant assays.

Fig. 5 HR-MS spectrum of celgosivir and its n-oxide impurity Fig. 6 HR-MS spectrum of castanospermin and its n-oxide impurity.

The fragmentation pattern difference observed was 16 mass number such as APIs and its n-oxide impurities (Table 1, Additional file 1).

Both raloxifene diquinone methide and its N-oxides were not detected by in situ UV vis spectroscopy and XPS analysis.

The active principle of roflumilast in man is its dichloropyridyl N-oxide metabolite, which has similar potency as a PDE4 inhibitor as the parent compound.

PAs can exist in two transmutable forms: the pro-toxic free base (tertiary amine) and its non-toxic N-oxide [19], [20].

For Tyria, senecionine N-oxygenase (SNO), a soluble enzyme located in the hemolymph, has been shown to convert the pro-toxic free base efficiently into its non-toxic N-oxide [22] (Figure 1).

Roflumilast is metabolized in the liver and its primary active metabolite, roflumilast N-oxide, is responsible for much of its pharmacodynamic activity (Huennemeyer et al. 2002a).