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Rejecting the distinctions made by Galen between various abstract faculties, Campanella states that the spiritus is singular and has its seat in the brain, from where, flowing through very subtle nerve channels, it accomplishes its multiple functions, both vital and cognitive.
Nevertheless, in the last decades, the recognition of its multiple functions has shown it to be a true regulator of blood flow and tissue homeostasis.
It is reasonable to consider that p73 would execute some of its multiple functions through the transcriptional regulation of cell context-specific target genes.
Moreover, recent studies have illuminated its multiple functions, including roles in cell proliferation, differentiation, and tumorigenesis.
Melatonin (N-acetyl-5-metoxytriptamine, MEL) has focused a lot of attention as consequence of its multiple functions.
Impassioned watch collectors will look behind appearances to appreciate the experimental use of new materials in a caliber, or the originality and complexity of its multiple functions.
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Smartphone has been recognized as one of the most powerful mobile carriers because of its portability, multiple functions, and wireless connectivity.
Due to its previous multiple functions, COX2 may participate in initiation, progression, invasion, and metastasis of cancer cells which are potential with clear prognostic implications and consequently contribute to the deterioration of human cancers [ 9].
Vitamin D has raised great interest in recent decades due to its multiple physiological functions, a including significant role in the regulation of the immune system [ 1– 7].
PI3-K regulates diverse cellular functions such as growth, survival and malignant transformation through its multiple enzymatic functions, namely lipid kinase and protein kinase activities [ 30, 31], and acts either synergistically with the Raf pathway [ 32] or in opposition to it [ 33].
In addition to its multiple described functions, our data suggest potential new roles for Pif1 in proteasome function, transcription coupled repair, endocytosis and vacuolar morphology, although some of these effects may be indirect if Pif1 has a transcriptional function.
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