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Guidant said it changed its manufacturing processes three years ago to fix the problem.
Dr. Bruce Burlington, senior vice president for regulatory affairs at Wyeth-Ayerst, the company's prescription drug subsidiary, said that the company regretted that it did not move more aggressively to change its manufacturing processes after it first received warnings from the F.D.A. as early as 1995.
He noted that Intel, which uses its own version of APM, tends to have less flexibility in its manufacturing processes once it starts building a chip.
Mr. Meidell of Cascade Designs said the improved performance in its manufacturing processes had helped it retain its three American plants.
Italian clothing manufacturer and retailer Benetton redesigned its manufacturing processes so that select products particularly those subject to extreme demand variability are made as generic, undyed items to be finished later, when the company obtains more accurate demand information.
*Ford Motor, no longer content with the $3 million or so that it reaped each year from licensing its manufacturing processes to other companies, recently appointed Damian Porcari, one of its intellectual property lawyers, to be director of technology commercialization.
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Boston Scientific said it had received no complaints about deflation problems with the stents made after it changed its manufacturing process.
SpaceX, founded by Elon Musk, a tech entrepreneur, revamped the design of the strut and its manufacturing process; it now individually tests every strut to ensure that each meets strength requirements.
The Indian government provided Apple tax concessions for the domestic assembly provided it used more local parts in its manufacturing process over time.
In addition to charge and glycosylation heterogeneity, aggregates may be caused by the irreversible denaturation of the mAb that occurs during its manufacturing process and shelf life; thus it is a property to be determined and controlled.
Intel says introducing strained silicon to its manufacturing process will add only 2% to the cost of processing a wafer.
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