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Even though MDM4 overexpression in MM is rare, its locus on chromosome 1q is frequently amplified [ 28]; thus it would be important not to rule out the possibility of nutlin resistance arising from this genetic deregulation.
A joint American-Philippine military exercise scheduled to begin in a few weeks will have its locus on Sulu, a group of islands in the middle of that zone.
But the exam also is a ritual, an important one, which when done well validates the patient's complaints and places its locus on the body, and not on a computer screen.
As FMRP has been identified as chromatin-associated, chromatin immunoprecipitation followed by sequencing (ChIP-seq) is necessary to clarify its locus on chromatin (if ChIP-grade anti-FMRP is available).
The most parsimonious explanation is that the MIB1 primer pair, although specific for its locus on the B11 serotype, may amplify several related MIB loci in the case of other serotypes.
The GSTM1 isozyme contains three main genotypes at its locus on chromosome 1p13: GSTM1*b, GSTM1*b and GSTM1*0.
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flo-3 is a floury endosperm mutant with a lower level of the 16-kDa allergenic protein and its locus is on chromosome 3 (Nishio and Iida1993).
In order to test whether gene-flow among MOTU exists, we have surveyed the nuclear ITS-1 locus on a regional scale in Switzerland, because three of the inferred MOTU (1, 2, and 5) coexist there in close proximity.
The repression of beta-isopropylmalate dehydrogenase, the LEU2 gene product, by leucine and leucine plus threonine was unaffected by the transposition of LEU2 from its original locus on chromosome III to a new locus within the ribosomal deoxyribonucleic acid gene cluster on chromosome XII.
Using the same methodology, we were able to map albinism to its known locus on chromosome 7 [ 30].
Thus, although tenascin-X is the most divergent family member in terms of protein sequence, its gene locus on chromosome 6q21.3 is paralogous with that of the tenascin-C and -R genes [ 44, 45].
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