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The "fold" metric is the level of activation of a signaling molecule after treatment with a modulator compared to its level of activation its basal state.
Macroautophagy thus has antagonistic roles during senescence, inducing cell death or promoting neoplastic transformation, depending on its level of activation.
Here we show that this senescence-associated macroautophagy determines the outcome of senescent keratinocytes, depending on its level of activation.
Thus, the amygdala may indeed modulate attention to threat, but its level of activation may be a function of both initial orienting and maintained attention.
Enhanced noradrenaline levels in the SC could alter the behavior of the EphA3KI/KI mice by modulating the signal-to-noise ratio in this structure (Mooney et al. 1990; Tan et al. 1999) and thereby changing its level of activation (Dommett et al. 2009).
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The biochemical basis for its high level of activation remains unclear to this day, as it does not appear that stability of the RNA complex directly correlates with its IFN inducing capacity (Colby and Morgan 1971).
This model would explain the stress priming results in more or less the same way as they are explained in a dual-process framework: The stress pattern is part of an output representation, and its resting level of activation can be modified by naming items with the same stress pattern.
Levels and subcellular localization of VRK2 may modulate different responses where the assembly of JIP1 complexes is required, since in its presence the level of activation will be lower the higher the level of VRK2 protein is.
GALT is recognized as a primary HIV target, irrespective of the mode of transmission, likely due to its constitutively high level of activation [9,10].
Our proposal that aging of the gastrocnemius progenitor cells and myofibers is delayed by reducing the levels of P-p38α activity in the DN-p38αAF/+ mouse is supported by the demonstration that its attenuation reduces the level of activation of cell cycle inhibitors of the Cdkn2a and Cdkn2b tumor suppressor loci in multiple organs (kidney, spleen, lung, liver) [ 24].
(2) The hierarchical layer determines each module's level of activation when its respective body part is coated in dust.
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