Because RIPK1 deficiency in mice causes postnatal death due to its indispensable platform function leading to NF- κB and mitogen-activated protein kinase signaling, Nec-1 has been instrumental in studying the contribution of RIPK1 kinase-dependent necroptosis in various pathologies involving cell death.
As one of the most important and abundant TEs that still active in human genome, Alu, a SINE family, has demonstrated its indispensable regulatory functions at sequence level, but its spatial roles are still unclear.
LAMC2 showed a high MM of 0.97 in the blue module, suggesting that it has an indispensable function (Additional file 3: Table S7).
At first hindered by government-imposed censorship, taxes, and other restrictions, newspapers in the 18th century came to enjoy the reportorial freedom and indispensable function that they have retained to the present day.
Path following is an indispensable function for autonomous vehicles.
Controllable polymer micropatterns, served as indispensable function structures, are extensively required in many micro/nano scientific areas and engineering applications.
Kant describes the function he had in mind as "a blind but indispensable function of the soul" (A78=B103), so he meant something rather different from what we now mean by the term 'imagination' (A120 and fn).
However, computers and technologies often play a subsidiary role in facilitating teaching and learning in nowadays schools rather than an indispensable function that deeply incorporated into the daily instructional practices (Bebell, Russell, & O'Dwyer, 2004; Ling Koh, Chai, & Tay, 2014).
Very few mutants for the regeneration process were isolated so far, illustrating the difficulty to identify genes that have an indispensable function during regeneration.
Evaluation of the role of these oxylipins in providing plant protection against two necrotrophic pathogens, B. cineara and A. brassicicola, further illustrate the indispensable function of jasmonates, and not C6-aldehyes in mediating the activation of direct plant-defense responses.
