Sentence examples for its functional effect from inspiring English sources
This variant maps to an intergenic region but it was hypothesized that it may exert its functional effect via the TNFAIP3 gene.
To determine if v3 might also contribute functionally to increased IDE expression, we evaluated its functional effect on reporter gene expression in vitro.
It may indicate that more samples are needed to determine its functional effect or the genetic variants impact on disease susceptibility by other mechanisms instead of cis-eQTL effect.
In a typical structure-function relation study, the primary structure of proteins or nucleic acids is changed by mutagenesis and its functional effect is measured via biochemical means.
Fourth, serotonin's role in migraine is not just determined by transporter activity, but also by its functional effect at the receptor level.
We reasoned that each SNP has a different effect on disease predisposition either increasing or decreasing the risk due to its functional effect on the regulation of the overall pathway output (Figure 1).
Whether or not vimentin expression directly affects the aggressiveness of pancreatic cancer cells because of its functional effects as an intermediate filament or whether it is merely a marker of a more aggressive cancer cell is not known.
"To date we've only focused on validating its functional effects, and not yet done any placebo-controlled trials — this is something we'll definitely explore," says a spokesman.
These results suggest that loss of TβRIII expression during multiple myeloma progression contributes to disease progression through its functional effects on increased cell growth, proliferation, motility, and adhesion.
Our observations suggest that epigenetic features may define the cellular microenvironment in which SYT-SSX displays its functional effects.
In this regard, it is tempting to link the presence of α1A-AR and cav-1 and to hypothesize that the α1A-AR could mediate via caveolae its functional effects on growth or survival of advanced stage PCa cells.
