The 4C6 monoclonal antibody and other p14ARF monoclonal antibodies have verified the nuclear/nucleoplasmic localisation of ARF with intactness of its functional pathway, as well as its implications as a prognostic surrogate marker compared with nucleolar ARF [ 27, 30].
He said he had designed it so things could be placed on its ledges, giving it a functional as well as spiritual dimension.
To thoroughly examine the role of APOE in MS, we genotyped its functional alleles, as well as seven single-nucleotide polymorphisms (SNPs) located primarily within 13 kb of APOE, in a data set of 398 families.
This endocytic mechanism might support the sustained expression of uPAR at its functional sites as well as ensuring the preservation of a constant membrane area.
Several biochemical approaches including polyacrylamide gel electrophoresis (PAGE), temperature gradient gel electrophoresis (TGGE), and atomic force microscopy (AFM) were implemented to confirm the formation of the triangular structures and its functional derivative, as well as to elucidate their properties.
Transient retention of CD4+ T cells within the perivascular space raises both the question of its functional relevance, as well as the identification of molecules regulating T cell access to the parenchyma.
We anticipate that similar strategies will reveal the mammalian ribosome in various stages of its functional cycle, as well as translation-related regulatory events that impact human physiology (e.g., (Chen et al., 2014).
While searches of this sort could be conducted 'not only at the border itself, but at its functional equivalents as well,' ibid., the Court concluded that the search at issue in the case 'was of a wholly different sort.' Id., at 273, 93 S.Ct. at 2539.
An alteration in forest structure through fragmentation of forests has affected its functional abilities, as is evident from the decline in water yield, carbon sequestration potential and biodiversity.
Studies of NMDAR signaling have been conducted and the role of NMDAR activity in apoptosis has been studied intensively in neurons [ 11, 12], as well as its functional role as a tumor suppressor in human tumors.
