Sentence examples for its essentiality for from inspiring English sources

Such a unique region which is absent in human enolase, constitutes an excellent target for inhibitor design, provided its essentiality for function could be demonstrated.

Its essentiality for mammalian life was discovered in 1957.

Helicase is considered to be a potential antimalarial target due to its essentiality for parasite life cycle [ 67].

Therefore, we speculated whether its essentiality for stationary phase survival might be related to adaptation to a condition where there is a shortage of available carbon sources.

On the other hand, EGFR-null sperm revealed very low binding to the oocyte as well as decreased IVF rate, emphasizing the role of EGFR and its essentiality for efficient sperm-egg interaction for normal fertilization [ 41].

To clarify which function is primarily responsible for its essentiality and the protein domain for such function, we performed dRecQ4 functional domain dissection experiments.

If diphthamide-deficient mutant eEF-2 proteins function perfectly well, it then becomes difficult to understand the retention of the diphthamide modification in such a diverse set of species, which argues strongly for its essentiality.

The C-terminal domain of dRecQ4 is dispensable for its essentiality, but the rescue efficiency of the truncated protein that lacks the C-terminal is only about 10% compared with the full length dRecQ4 protein.

We evaluated each native gene for its essentiality considering expression levels, phylogenetic conservation, and knockout data.

The BMP signaling pathway is well known for its essentiality in many developmental processes [ 45].

Failure to disrupt a gene provides insufficient evidence for its essentiality.