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Given its essential functions in various essential cellular pathways, it is not surprising that defects in the ubiquitin system have been linked to numerous diseases such as cancer, inflammation, central nervous system disorders and metabolic dysfunctions.
Close the Department for International Development (DfID) and merge its essential functions with the Foreign Office.
Ukip wants to close the department, merging its "essential functions" with the Foreign and Commonwealth Office, but keep a single minister for overseas development.
The EIU's index is based on an (unweighted) assessment of 12 indicators that collectively capture a state's ability to deliver its essential functions.
Notwithstanding Jackson's claims to the contrary, many critics – this writer included – believe that the 40-year experiment with a freestanding Environmental Protection Agency has been a failure and that the agency should be abolished, its essential functions reassigned to other, less scientifically-challenged government organisations.
In the nonmonetary Egyptian economy, its essential functions were the collection, storage, and redistribution of produce; the drafting and organization of manpower for specialized labour, probably including irrigation and flood protection works, and major state projects; and the supervision of legal matters.
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Certainly it might be more fun, but at the same time, in some ways it undermines its essential function, which is to move people and objects safely and not be just another road rocket.
Thus, in parB mutants only a very small proportion of cellular Smc ScpAB is bound to chromosomes within the replication origin region, where it presumably performs its essential function by promoting the separation of nascent sister chromosomes (Gruber et al., 2014; Wang et al., 2014).
A urinal is not an art object as long as it is carrying out its essential function.
In a recent interview he added: "The beauty of the bass is that its essential function is for dancing.
"If consulting activities distort the views that law faculty espouse as scholars, then academic freedom is failing to perform its essential function," Eisenberg said.
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